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alinia off label in combo with entecavir or tenofovir
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By:
lobba123
Postings:
11
From:
n/a
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Posted:
Sat Feb 13, 2010 - 09:26 PM
did anybody try alinia off label in combo with firstline hbv antivirals entecavir or tenofovir?
alinia lowers hbs and hbe antigens leading to seroconversion in a very high rate in mono tx and combo but has not been tried yet with entecavir or tenofovir (only tried with lamivudine and adefovir which are old weak, ineffective and dangerous drugs for hbv)
i am currently on entecavir and planning combo with tenofovir by 1-2 years as we have trial results on this combo in october of this year but i am also very interested in trying alinia too because of the high seroconversion reported
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By:
brit
Postings:
46
From:
n/a
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Posted:
Sun Feb 21, 2010 - 09:27 AM
Lobba
I do not think you should simply call adefovir ineffective and dangerous......it is true that lamivudine monotherapy is now not being recommended by many specialists as it has a high resistance profile and it is also true that entecavir and tenfovir have MUCH better resistance profiles but in my case adefovir has been both VITAL and safe.
The reason I say this is that I was on entecavir monotherapy in 2006 which was only partially successful (reduced the virus but not enough) and about 18 months later Adefovir was added to the combination and this got me quickly to being viral negative and losing my E antigen.....I have also not had any real side effects from Adefovir.
I think the point you are making is that entecavir and tenfovir have good resistance records so on that point I would agree but in my case adding adefovir to entecavir proved to be the right choice and in this combination resistance is highly unlikely.
I do think that your combo of Entecavir and Tenofovir makes a lot of sense ....so good luck with it.
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By:
lobba123
Postings:
11
From:
n/a
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Posted:
Mon Mar 01, 2010 - 11:38 PM
of course i mean these meds are useless now in 2010 not 2006 (actually i have waited until now to start tx from 2000 because of the more potent and safe meds now available)
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By:
brit
Postings:
46
From:
n/a
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Posted:
Sun Mar 07, 2010 - 09:05 AM
I still disagree with you when you simply say that Adefovir is useless.......for people who take entecavir monotherapy who given time only have a partial/sub-optimal response , adding adefovir to entecavir is a very sensible option......and according to my specialist that still holds in 2010...
As I said before I think the point you are making is that lamivudine (in particular) and adefovir first-line MONOtherapy are much less favoured these days (due to the resistance risk) and so first-line treatment MONOtherapy with Entecavir and Tenofovir is now preferred
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By:
lobba123
Postings:
11
From:
n/a
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Posted:
Tue Mar 09, 2010 - 09:56 PM
well in italy is no longer used from 2009
i suggest http://www.medhelp.org/forums/Hepatitis-B/show/223
there are posts from an hepatitis researcher who co-developped with others all hbv antivirals.
if you search his posts under HR you might find very crazy how the researcher needed to post on internet to save people from weak and dangerous antivirals (lam, adefovir)choosen by the market and why the market has choosen them.
It is even more funny that he knew before 2001 that tenofovir was the strongest antiviral (not lam and adefovir) and somebody close to him started treatment for hbv with it off label in 2001 avoiding lam and adefovir and their resistance dangers
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By:
brit
Postings:
46
From:
n/a
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Posted:
Sun Apr 04, 2010 - 11:36 AM
I will for the last time comment on this. I still feel we are speaking at cross purposes.
I totally understand and agree with you on your point about the downside risk to first-line SINGLE-use Adefovir resistance.
I maintain my total satisfaction with the careful decision my specialist and made to add Adefovir to my Entecavir treatment as when I took Entecavir alone I had a suboptimal response.
Not only did the Adefovir addition make me viral negative , I also lost my e antigen. This was a big step forward for me.
As I am taking Adefvoir in COMBINATION therapy the fact that it is a combination greatly reduces the risk of long-term resistance.
I hope we can drop this discussion now but if not this will be my last comment on Adefovir
I found your other comment on the exciting results from the Asia Pacific conference on some new treatment very interesting by the way....... |
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